Email this article Rare clinical case of diffuse B-large cell lymphoma with laryngeal lesion
- Authors: Kamaeva I.A.1, Lysenko I.B.1, Engibaryan M.A.1, Gusareva M.A.1, Legostaev V.M.1, Lapteva T.O.1, Nikolaeva N.V.1, Gaysultanova Y.S.1, Kapuza E.A.1, Samaneva N.Y.1, Ulyanova Y.V.1, Volkova V.L.1, Bauzhadze M.V.1, Balizkiy G.V.1, Tolmacheva E.A.1
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Affiliations:
- National Medical Research Centre for Oncology
- Issue: Vol 27, No 1 (2022)
- Pages: 29-36
- Section: Case Reports
- URL: https://rjonco.com/1028-9984/article/view/109580
- DOI: https://doi.org/10.17816/onco109580
- ID: 109580
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Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common variant of non-Hodgkin’s lymphoma and accounts for 30–60% of all non-Hodgkin’s lymphomas, with increasing incidence increases with age. Currently, the prognosis is assessed using the International Prognostic Index. In recent years, in all European regions, there has been a significant improvement in survival in DLBCL due to the addition of rituximab to standard chemotherapy (CHOP protocol). However, despite significant advances in treatment, long-term remission is only achieved in half of the patients. Laryngeal lesions with this variant of lymphomas is described only in a few articles. There is evidence of various chemotherapeutic regimens effective in this type of lymphoma; in some publications, the authors suggest the use of radiation therapy.
The article presents a clinical case of successful treatment of a patient (chemotherapy + radiation therapy) with diffuse large B-cell lymphoma with laryngeal involvement. with resulting remission. In addition, a review of the literature describing the most common types of lymphomas is presented. The authors set a goal to raise the awareness of physicians about a rare histological variant of laryngeal tumors with a rapid increase in clinical manifestations and the development of life-threatening conditions.
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About the authors
Inna A. Kamaeva
National Medical Research Centre for Oncology
Author for correspondence.
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0003-3001-0675
SPIN-code: 8953-3351
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonIrina B. Lysenko
National Medical Research Centre for Oncology
Email: iralyss@rambler.ru
ORCID iD: 0000-0003-4457-3815
SPIN-code: 9510-3504
MD, Dr. Sci. (Med.), Professor
Russian Federation, 63 14th line, 344037 Rostov-on-DonMarina A. Engibaryan
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0001-7293-2358
SPIN-code: 1764-0276
MD, Dr. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonMarina A. Gusareva
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 9040-5476
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonVladislav M. Legostaev
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 6573-8672
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonTatyana O. Lapteva
National Medical Research Centre for Oncology
Email: lto-96@yandex.ru
SPIN-code: 2771-3213
Russian Federation, 63 14th line, 344037 Rostov-on-Don
Nadezhda V. Nikolaeva
National Medical Research Centre for Oncology
Email: nadya.nikolaeva.74@bk.ru
ORCID iD: 0000-0001-7224-3106
SPIN-code: 4295-5920
MD, Dr. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonYakha S. Gaysultanova
National Medical Research Centre for Oncology
Email: yakha.gaysultanova@mail.ru
ORCID iD: 0000-0003-2785-1721
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonElena A. Kapuza
National Medical Research Centre for Oncology
Email: kapuzaea1967@mail.ru
ORCID iD: 0000-0002-0761-2486
SPIN-code: 4430-1151
Oncologist
Russian Federation, 63 14th line, 344037 Rostov-on-DonNatalya Yu. Samaneva
National Medical Research Centre for Oncology
Email: prettyfairy19@rambler.ru
ORCID iD: 0000-0003-0843-6012
SPIN-code: 1181-0659
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonYulia V. Ulyanova
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 1276-9063
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonViktoria L. Volkova
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
ORCID iD: 0000-0003-2674-0755
SPIN-code: 8289-6300
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonMamuka V. Bauzhadze
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 5315-3382
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonGennadiy V. Balizkiy
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 4090-2703
Russian Federation, 63 14th line, 344037 Rostov-on-Don
Ekaterina A. Tolmacheva
National Medical Research Centre for Oncology
Email: inkamaeva@yandex.ru
SPIN-code: 2376-0705
MD, Cand. Sci. (Med.)
Russian Federation, 63 14th line, 344037 Rostov-on-DonReferences
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