PROGNOSTIC SIGNIFICANCE OF COMPUTER-AIDED PLOIDOMETRY IN RENAL CELL CARCINOMA



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Abstract

We have investigated the prognostic significance of DNA computer morphometry in the nuclei of tumor cells in renal cell carcinoma (RCC). Surgical specimens of 108 patients with renal cell carcinoma was the material for investigation. The mean age was 57,8 ± 0,9 years. Males were 49 (45.3%), women - 59 (54.6%). Correlation relationship was revealed between index of DNA accumulation (INDNK) in the nuclei of tumor cells with clinical stage (r = 0,64; p = 0,0001), the size of the tumor node (r = 0,44; p = 0,0001), the presence of regional and distant metastases (r = 0,68; p = 0,0001), Fuhrman tumor grading (r = 0,75; p = 0,001). No relationship of INDNK with sex (r = 0,10; p = 0,30), age (r = 0,08; p = 0,41) and patients with histological types of tumors (r = 0,09; p = 0, 32) was revealed. During Cox multivariate regression analysis, the following independent predictors of RCC were revealed: the presence of regional and distant metastases (p = 0,0008), the degree of Fuhrman nucleus atypia (p = 0,005); stage by TNM (p = 0,03) and ploidy (p = 0.03). Such clinical - anatomical factors such as gender, age, tumor size and histological types of tumor didn;t have prognostic significance in assessing the 5 - year survival rate of patients. Thus, the ploidy of tumor cells is a significant prognostic parameter along with the classical prognostic factors in RCC.

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Прогностическое значение компьютерной плоидометрии при почечно-клеточном раке
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About the authors

T. M Cherdantseva

The Altay state of medical university

Email: drakon@agmu.ru
656038, Barnaul, Russian Federation

I. P Bobrov

The Altay state of medical university

656038, Barnaul, Russian Federation

V. V Klimachev

The Altay state of medical university

656038, Barnaul, Russian Federation

V. M Bryukhanov

The Altay state of medical university

656038, Barnaul, Russian Federation

A. F Lazarev

Altay branch of N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

A. M Avdalyan

Altay branch of N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences

656049, Barnaul, Russian Federation

A. Yu. Dolgatov

The Altay state of medical university

656038, Barnaul, Russian Federation

A. V Kazartsev

The Altay state of medical university

656038, Barnaul, Russian Federation

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