Prevention of post-radiation damage to the bladder with medicinal plants in patients with locally advanced forms of cervical cancer

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Abstract

Objective: to study the effect of phytotherapy on the frequency and extent of post-radiation injuries in patients with locally advanced forms of cervical cancer who received chemo-radiation treatment.

Material and methods: a randomized clinical trial was conducted, including 2 groups of patients aged 24–64 years with a morphologically confirmed diagnosis of locally advanced (IIb–IIIb) cervical cancer. The main group consisted of 350 patients who received standard chemo-radiation therapy against the background of therapy with medicinal plants using the original patented method, and a comparison group of 402 patients who received only standard special treatment.

Results: accompanying therapy with medicinal plants reduces the risk of early post-radiation complications of the bladder (erosive cystitis) in patients of the main group by 1.4 times [2.9 ± (3.7–2.1) % vs. 4.0 ± (5.0–3.0)% ; p = 0.0001]; late (5 years after treatment) – 2.9 times [0.9 ± (0.96–0.84) % vs. 2.6 ± (3.7–1.5) %; p = 0.0001].

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About the authors

S. V. Korepanov

Altay State Medical University

Email: valent_04@mail.ru
ORCID iD: 0000-0001-9734-9484
Russian Federation, Barnaul

A. F. Lazarev

Altay State Medical University; Altai Branch of the N.N. Blokhin Cancer Research Center of the Ministry of Health of Russia

Email: valent_04@mail.ru
ORCID iD: 0000-0003-1080-5294
Russian Federation, Barnaul

M. G. Nikolaeva

Altay State Medical University

Email: valent_04@mail.ru
ORCID iD: 0000-0001-9459-5698
Russian Federation, Barnaul

V. D. Petrova

Altay State Medical University; Altai Branch of the N.N. Blokhin Cancer Research Center of the Ministry of Health of Russia

Author for correspondence.
Email: valent_04@mail.ru
ORCID iD: 0000-0001-7169-9646

MD, PhD, associate professor of the department of oncology, radiation therapy and radiation diagnostics with the course of supplementary vocational education, Altai State Medical University of the Ministry of Healthcare of the Russian Federation

Russian Federation, Barnaul

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