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Vol 25, No 2 (2020)

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Basic Science - Practical Health Care

Robotic intelligence in the organization of pre-medical diagnostics of the risk of tumor diseases

Cherenkov V.G., Pasevich K.G., Gulkov I.V.


Based on the creation of a robotic complex, the analysis of clinical observations of 1053 patients was carried out, by means of a survey with illustrations, in which 106 (30.4 ± 4.6%) later revealed a malignant process. In 53 patients with microscopy of pigmented nevi, other tumors and precancerous changes in visual localization, oral cavity, in which 13 (72.2% ± 1.1) had melanoma and other tumors. In 75 patients, based on the survey, a urease breath test was required, on the basis of which, if it was present for more than 10 units, FGS was performed, while in 12 cases, peptic ulcer in the acute stage or scarring, chronic gastritis with metaplasia zones, and in 4 (11.7 ± 0.9), stomach cancer was detected. The survey was conducted with the participation of clinical residents and students on Open days and at the request of patients after 3 advertising exhibitions

Russian Journal of Oncology. 2020;25(2):72-76
pages 72-76 views

Clinical investigations

Prevention of post-radiation damage to the bladder with medicinal plants in patients with locally advanced forms of cervical cancer

Korepanov S.V., Lazarev A.F., Nikolaeva M.G., Petrova V.D.


Objective: to study the effect of phytotherapy on the frequency and extent of post-radiation injuries in patients with locally advanced forms of cervical cancer who received chemo-radiation treatment.

Material and methods: a randomized clinical trial was conducted, including 2 groups of patients aged 24–64 years with a morphologically confirmed diagnosis of locally advanced (IIb–IIIb) cervical cancer. The main group consisted of 350 patients who received standard chemo-radiation therapy against the background of therapy with medicinal plants using the original patented method, and a comparison group of 402 patients who received only standard special treatment.

Results: accompanying therapy with medicinal plants reduces the risk of early post-radiation complications of the bladder (erosive cystitis) in patients of the main group by 1.4 times [2.9 ± (3.7–2.1) % vs. 4.0 ± (5.0–3.0)% ; p = 0.0001]; late (5 years after treatment) – 2.9 times [0.9 ± (0.96–0.84) % vs. 2.6 ± (3.7–1.5) %; p = 0.0001].

Russian Journal of Oncology. 2020;25(2):61-66
pages 61-66 views

Original Study Articles

Invasive potential of retroperitoneal well-differentiated liposarcomas depending on the extent of sclerosing component in the tumor

Volkov A.Y., Kozlov N.A., Nered S.N., Stilidi I.S., Stroganova A.M., Archery P.P., Antonov E.Y., Privezentsev S.A.


Objective. To assess the influence of the extent of sclerosing component in the retroperitoneal well-differentiated liposarcoma (WDLPS) on the survival.

Material and methods. The retrospective study included 111 patients with primary retroperitoneal WLPS who underwent radical surgical treatment in Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology». Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013). Patients were divided into groups depending on the extent of the sclerosing component in the tumor and enrolled in intergroup analysis. We analyzed relationship between extent of the sclerosing component in the tumor and frequency of the pathologically confirmed visceral invasion. Also, we have analyzed the influence of the visceral invasion of WDLPS on the long-term results – overall (OS) and recurrence-free (RFS) survival.

Results. Pathologically confirmed visceral invasion was revealed in 17% of cases with the sclerosing component less 20%, and in 31% of cases with the sclerosing component more 20%. OS was significantly worse in the group of patients who suffered from WDLPS with visceral invasion than in the group of patients without visceral invasion (p = 0.009; logarithmic criterion). The median OS in the compared groups was 85 (95% CI, 84, 87) and 142 (95% CI, 109, 175) months, the 5-year OS rate was 41% and 86%, respectively. RFS was significantly worse in the group of patients with histologically confirmed visceral invasion than in the group without organ invasion (p = 0.001; logarithmic criterion). Median RFS in the compared groups was 26 (95% CI, 20, 32) and 57 (95% CI, 38, 76) months, 2-year RFS 33% and 85%, respectively.

Conclusion. Results of the study demonstrate more aggressive behavior of WDLPS with increasing extent of the sclerosing component. We believe that semi-quantitative counting of sclerosing component in retroperitoneal WDLPS can serve as an effective morphological marker of a less favorable prognosis of the disease.

Russian Journal of Oncology. 2020;25(2):50-55
pages 50-55 views

Association of gene expression with lymph node breast cancer metastasis

Grishina K.A., Kipkeeva F.M., Pospekhova N.I., Khaylenko V.A., Karpukhin A.V.


The most serious complication of breast cancer (BC), which affects life expectancy, is metastasis of the tumor. Metastasis is the cause of more than 80% of all breast cancer deaths. After surgical treatment and the use of adjuvant therapy, metastases occur in 8% – 15% of cases. This indicates the need to develop markers for the prognosis of metastasis and clarify its mechanisms for the creation of anti-metastatic therapeutic agents. In this paper, we studied the association of LOX and uPAR gene expression with breast cancer metastasis in the lymph nodes.

Gene expression was measured using real-time PCR in 40 paired samples (tumor-normal tissues). As a result of processing the measurements, the values of gene expression levels in the tumor tissue relative to normal were obtained.

It is shown that the LOX gene is expressed in the tumor both lower and higher relative to the norm, and uPAR is expressed in most cases higher. In metastatic tumors, the frequency of expression increases above the norm for both LOX and uPAR genes. The association of expression of these genes with lymphatic metastasis was found: p = 0.01 and p = 0.02, for the LOX and uPAR genes, respectively. The relative risk (RR) was for the LOX gene RR = 1.9, 95% CI 1.2 – 3, p = 0.005, for uPAR RR = 3.6, 95% CI 1.2 – 10.9, p = 0.03.

Thus, the data obtained contribute to understanding the mechanisms of metastasis and provide the basis for the development of new biomarkers. The LOX and uPAR genes may be candidates for predictive markers of breast cancer metastasis risk.

Russian Journal of Oncology. 2020;25(2):56-60
pages 56-60 views

Case Reports

Covid-19 with chemoradiotherapy for esophageal cancer. Clinical case

Sultanbaev А.V., Musin S.I., Menshikov К.V., Izmaylov А.А.


In a pandemic of a new coronovirus infection, patients with malignant neoplasms fall into a special risk group. A clinical case of COVID-19 infection in a patient receiving chemoradiotherapy is presented. The patient received chemoradiotherapy for esophageal cancer and was suspended due to the development of leukopenia. On the 2nd day after discharge from the hospital, the patient developed symptoms of SARS. According to computed tomography signs of viral pneumonia, according to PCR smear revealed RNA of coronavirus SARS (SARS-CoV-2). The patient underwent antiviral, anticoagulant, antibacterial therapy, hematopoietic stimulants, glucocorticosteroids, and immunosuppressant. Conducted CT control in dynamics. On day 14, an improvement was noted, normalization of body temperature, according to CT data on day 14, the volume of lung damage decreased from 45% to 10%, smears on RARS coronavirus RNA (SARS-CoV-2) on 5.10, 14 days after hospitalization were negative. On the 18th day, the patient was discharged with recovery under the supervision of a therapist and continued antitumor treatment. A clinical case demonstrates a successful recovery from COVID-19 against the background of chemoradiotherapy for esophageal cancer complicated by lymphopenia and leukopenia.

Russian Journal of Oncology. 2020;25(2):67-71
pages 67-71 views

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