Covid-19 with chemoradiotherapy for esophageal cancer. Clinical case

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Abstract

In a pandemic of a new coronovirus infection, patients with malignant neoplasms fall into a special risk group. A clinical case of COVID-19 infection in a patient receiving chemoradiotherapy is presented. The patient received chemoradiotherapy for esophageal cancer and was suspended due to the development of leukopenia. On the 2nd day after discharge from the hospital, the patient developed symptoms of SARS. According to computed tomography signs of viral pneumonia, according to PCR smear revealed RNA of coronavirus SARS (SARS-CoV-2). The patient underwent antiviral, anticoagulant, antibacterial therapy, hematopoietic stimulants, glucocorticosteroids, and immunosuppressant. Conducted CT control in dynamics. On day 14, an improvement was noted, normalization of body temperature, according to CT data on day 14, the volume of lung damage decreased from 45% to 10%, smears on RARS coronavirus RNA (SARS-CoV-2) on 5.10, 14 days after hospitalization were negative. On the 18th day, the patient was discharged with recovery under the supervision of a therapist and continued antitumor treatment. A clinical case demonstrates a successful recovery from COVID-19 against the background of chemoradiotherapy for esophageal cancer complicated by lymphopenia and leukopenia.

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About the authors

А. V. Sultanbaev

Republican clinical oncology dispensary of Ministry of Healthcare of the Republic of Bashkortostan

Author for correspondence.
Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-0996-5995

Head of Antitumor Drug Therapy Department, Bashkir State Medical University of the Ministry of healthcare of the Russian Federation

Russian Federation, Ufa

S. I. Musin

Republican clinical oncology dispensary of Ministry of Healthcare of the Republic of Bashkortostan; Bashkir State Medical University of the Ministry of healthcare of the Russian Federation

Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-1185-977X
Russian Federation, Ufa

К. V. Menshikov

Republican clinical oncology dispensary of Ministry of Healthcare of the Republic of Bashkortostan; Bashkir State Medical University of the Ministry of healthcare of the Russian Federation

Email: rkodrb@yandex.ru
ORCID iD: 0000-0003-3734-2779
Russian Federation, Ufa

А. А. Izmaylov

Republican clinical oncology dispensary of Ministry of Healthcare of the Republic of Bashkortostan; Bashkir State Medical University of the Ministry of healthcare of the Russian Federation

Email: rkodrb@yandex.ru
ORCID iD: 0000-0002-8461-9243
Russian Federation, Ufa

References

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  3. Zhao S., Lin Q., Ran, Musa S.S., Yang, Wang et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak. Int. J. Infect. Dis. 2020; 92: 214–7. doi: 10.1016/j.ijid.2020.01.050.
  4. Du Toit. Outbreak of a novel coronavirus. Nat. Rev. Microbiol. 2020: 18 (3): 123. doi: 10.1038/s41579-020-0332-0.
  5. Kaprin A.D., Starinsky V.V., Petrova G.V., eds. Malignant neoplasms in Russia in 2017 (morbidity and mortality). Moscow Cancer Research Institute named after P. A. Herzen of the Federal State Budgetary Institution Scientific Research Center for Radiology of the Ministry of Health of Russia, 2018.
  6. Kaprin A.D., Starinsky V.V., Petrova G.V., eds. The status of anticancer healthcare for the population of Russia in 2018. Moscow Cancer Research Institute named after P.A. Herzen – a branch of the Federal State Budgetary Institution Scientific Research Center for Radiology of the Ministry of Health of Russia, 2019.
  7. Information about new coronavirus infection for medical personnel. Version no.6 from 04/28/2020. Available at: https://www.rosminzdrav.ru/ministry/med_covid19. (Last access 01.06.2020).

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