Epidemiological features of cervical malignancies in the Altai region

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Abstract


Objective: This study aimed to investigate the epidemiological features of cervical malignancies in the Altai region.

Material and methods. This study used data from the cancer register of the Altai Regional Cancer Center in Barnaul City. The cancer register records data of approximately 253,000 patients with malignant neoplasms, including 12,259 women with cervical cancer. We evaluated the “rough” (per 100,000 female populations) and standardized (world standard per 100,000 female populations) indicators of morbidity and mortality of cervical malignancies in Altai region within 20 years. The dynamics of the incidence and mortality of cervical cancer was analyzed by year and age groups.

Results: For the 1989–2018 period in the Altai region, a significant shift was found in the incidence of cervical cancer, which tends to increase in young population of reproductive age. During the 2008–2018 period, no positive changes were noted in the indicators of early diagnosis, i.e., no changes were found in the proportion of patients diagnosed with stage I and II (%) cervical cancer for the first time and the proportion of patients with stage III and IV (%) cervical cancer. The proportion of women who died from cervical cancer in the structure of oncogynecological diseases in the Altai region exceeds that in the Russian Federation.


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About the authors

S. V. Korepanov

Altai State Medical University

Email: valent_04@mail.ru
ORCID iD: 0000-0001-9734-9484

Russian Federation, 656049, Barnaul

A. F. Lazarev

Altai State Medical University

Email: valent_04@mail.ru
ORCID iD: 0000-0003-1080-5294

Russian Federation, 656038, 40, Lenin Ave., Barnaul

M. G. Nikolaeva

Altai State Medical University

Email: valent_04@mail.ru
ORCID iD: 0000-0001-9459-5698

Russian Federation, 656038, 40, Lenin Ave., Barnaul

Valentina D. Petrova

Altai State Medical University

Author for correspondence.
Email: valent_04@mail.ru
ORCID iD: 0000-0001-7169-9646

Russian Federation, 656038, 40, Lenin Ave., Barnaul

Ph.D., Altai State Medical University, 656038, 40, Lenin Ave., Barnaul, Russian Federation

References

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;Sep.12;68(6):394-424. doi: 10.3322/caac.21492. Epub. 2018 Sep 12.
  2. World Source: Globocan 2018. Available from: http://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf.
  3. Cervix. Estimated age-standardized incidence rates (World) in 2018, worldwide, females, all ages. International Agency for Research on Cancer. Cancer Today. Available from: http://gco.iarc.fr/today/online-analysis-multi-bars?v=2018& mode=cancer&mode_population.
  4. Kaprin AD, Starinsky VV, Petrova GV. Malignant neoplasms in Russia in 2018 (morbidity and mortality ). Moscow: MNIOI im. P.A. Herzen — branch FGBI «NERC» Ministry of health of Russia; 2019: 250. (In Russ).
  5. Petrova GV. Cervical cancer. Dynamics of the main statistical indicators. Materials of the National Congress “Oncology of the reproductive organs: from prevention and early detection to effective treatment”(may 19-21, 2016. Moscow); 2016:134. (In Russ).
  6. Sushinskaya TV, Zhordania KI, Payanidi YuG. Analytical aspects of oncological diseases of the female population of Russia. Oncogynecology. 2015;(3):40–3. (In Russ).
  7. Cervical cancer. Clinical guidelines. Moscow; 2020.
  8. Lazarev AF. Territorial Cancer Registry. Certificate of state registration of a computer program (2008611703). March 31, 2008. (20088610743). Feb 26, 2008. Federal Service for Intellectual Property, patents and trademarks. (In Russ).

Supplementary files

Supplementary Files Action
1.
Fig. 1. Incidence and Mortality Rates for Malignant Cervical Neoplasm in Altai Territory, 1998 (age-standardized rates, per 100 000 female population, worldwide standard)

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2.
Fig. 2. Incidence and Mortality Rates for Malignant Cervical Neoplasm in Altai Territory, 2018 (age-standardized rates, per 100 000 female population, worldwide standard)

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3.
Fig. 3. Proportion of Cervical Cancer in stage I–II, Russian Federation and Altai Territory, 2010–2018 (%)

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4.
Fig. 4. Proportion of Cervical Cancer in stage III–IV, Russian Federation and Altai Territory, 2010–2018 (%)

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5.
Fig. 5. Dynamics of proportion of cervical cancer in patients the age of 15–29 y.o., 2008–2019 (%)

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6.
Fig. 6. Dynamics of mortality rate for Cervical Cancer in patients at the age of 15–29 y.o. in the Russian Federation and the Altai Territory, 2008–2019 (per 100 000 female population)

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7.
Fig. 7. The proportion of deaths from Cervical Cancer in female patients at the age of < 40 y.o., Russian Federation and Altai Territory, 2018

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