Histopathological examination of surgical breast cancer specimens after neoadjuvant chemotherapy using digital radiography

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The article provides a literature overview on significance, pathologic assessment of residual disease problems, and digital radiography (DR) potential in breast cancer (BC) after neoadjuvant therapy (NAT). Within the framework of the paper, the authors carry out an analysis of the Russian and English-language publications from PubMed, Google Scholar, ClinicalTrials.gov, eLibrary, and Cyberleninka. The comparison of the Russian clinical guidelines for BC diagnosis and the European and American guidelines revealed a lack of information on DR usage in the morphological assessment. The review showed the international experience in DR usage and demonstrated the relevance of the solution of morphological assessment problems in BC regression degree after NAT due to necessary clinical trial protocol standardization and increased predictive residual tumor class significance. The DR facilitated the morphological identification of metal markers implanted into the tumor bed, microcalcifications, altered foci, and improved tumor bed visibility, which is important for further objective status assessment of the resection margins and residual cancer burden class. The authors consider it necessary to conduct a study to optimize the residual tumor assessment using DR.

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Inessa M. Telezhnikova

Loginov Moscow Clinical Scientific Center; Research Center for Obstetrics, Gynecology and Perinatology

Author for correspondence.
Email: i.telezhnikova@inbox.ru
ORCID iD: 0000-0002-1491-2882

Junior Researcher of the Histopathology Laboratory

Russian Federation, 86, Enthusiastov shosse, Moscow, 111123; Moscow

Galiya R. Setdikova

Loginov Moscow Clinical Scientific Center; Vladimirsky Regional Clinical Research Institute

Email: g.setdikova@mknc.ru
ORCID iD: 0000-0002-5262-4953

Doctor of Science, Leading Researcher of the Histopathology Laboratory

Russian Federation, 86, Enthusiastov shosse, Moscow, 111123; Moscow

Sergey G. Khomeriki

Loginov Moscow Clinical Scientific Center

Email: s.khomeriki@mknc.ru
ORCID iD: 0000-0003-4308-8009

Doctor of Science, Professor, Head of the Histopathology Laboratory

Russian Federation, 86, Enthusiastov shosse, Moscow, 111123

Ludmila G. Zhukova

Loginov Moscow Clinical Scientific Center

Email: l.zhukova@mknc.ru
ORCID iD: 0000-0003-4848-6938

Doctor of Science, Professor, Deputy Director for oncology

Russian Federation, 86, Enthusiastov shosse, Moscow, 111123


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1. Fig. X-ray imaging system for the Pathology Laboratory

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