Email this article Effect of luteinizing hormone-releasing hormone agonists on the testosterone levels and quality of life in patients with locally advanced and generalized prostate cancer
- Authors: Sokov DG1, Rusakov IG1, Sokov DG1, Rysakov IG1
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- Issue: Vol 16, No 1 (2011)
- Pages: 33-36
- Section: Articles
- URL: https://rjonco.com/1028-9984/article/view/39811
- DOI: https://doi.org/10.17816/onco39811
- ID: 39811
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Abstract
Prostate cancer (PC) was 5% of all revealed male malignancies in the Russian Federation in 2009. Among 23845 detected patients with PC, 53.4% had its Stage III or IV.
This paper gives the results of a follow-up of patients with locally advanced and generalized PC treated by different hormonal therapy regimens. The purpose of the study was to search for the optimal hormonal therapy regimen, by maintaining the quality of life, whose criteria were potency level, libido, and normal physical activity.
The follow-up data may lead to the conclusion that the 6-month use of luteinizing hormone-releasing hormone (LHRH) agonists causes an irreversible reduction in potency and libido and a considerable decrease in testosterone levels. Sustained-release LHRH agonists decrease testosterone levels (below 20 ng/dl), are an easy-to-use and simple dosage form, and may be recommended for outpatient administration.
This paper gives the results of a follow-up of patients with locally advanced and generalized PC treated by different hormonal therapy regimens. The purpose of the study was to search for the optimal hormonal therapy regimen, by maintaining the quality of life, whose criteria were potency level, libido, and normal physical activity.
The follow-up data may lead to the conclusion that the 6-month use of luteinizing hormone-releasing hormone (LHRH) agonists causes an irreversible reduction in potency and libido and a considerable decrease in testosterone levels. Sustained-release LHRH agonists decrease testosterone levels (below 20 ng/dl), are an easy-to-use and simple dosage form, and may be recommended for outpatient administration.
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References
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