Giant condiloma of Bushke–Löwenstein: a clinical case

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Giant condyloma Buschke-Levenshtein is a large, exophytic, slow-growing, benign, warty lesion of the anogenital region. The cause of this pathology is infection with the human papillomavirus, mainly of the 6th or 11th type. The pathogenesis of giant genital warts is not well understood, and it is often considered an intermediate link between acute warts and squamous cell carcinoma. The frequency of occurrence in the general population is about 0.1%, which indicates the rarity of this pathology. The giant condyloma Buschke-Löwenstein was first described by the authors Buschke and Löwenstein in 1925. Currently, the literature contains descriptions of mostly single observations of patients with this pathology. The main method of treatment for giant condyloma Buschke-Levenshtein is surgical, the task of which is a wide excision of the tumor within healthy tissues. We present a clinical observation of a patient with a giant condyloma Buschke-Levenshtein. a 36-year-old patient underwent surgical treatment - removal of a large perineal tumor. At the time of surgery, the size of the tumor was about 25 × 15 cm. The patient underwent surgical treatment without complications, healing by primary intention. Within six months after the operation, no recurrence of the disease was detected. Thus, surgical treatment of such tumors is the only method that can count on the patient being cured.

Full Text

Restricted Access

About the authors

Konstantin V. Menshikov

Bashkir State Medical University

Author for correspondence.
Email: kmenshikov80@bk.ru

MD, PhD, oncologist of the Department of Chemotherapy of the Republican Clinical Oncological Dispensary, 450054, Ufa, Russian Federation, Associate Professor of the Department of Oncology with courses oncology and pathological anatomy, Bashkir State Medical University, 450008, Ufa, Russian Federation

Russian Federation, 450008, Ufa

O. N. Lipatov

Bashkir State Medical University

Email: kmenshikov80@bk.ru
Russian Federation, 450008, Ufa

S. F. Nasyrova

Bashkir State Medical University

Email: kmenshikov80@bk.ru
Russian Federation, 450008, Ufa

References

  1. Sandhu R, Min Z, Bhanot N. A gigantic anogenital lesion: buschke-lowenstein tumor. Case Rep Dermatol Med. 2014;650714. doi: 10.1155/2014/650714. Epub 2014 Nov 6.
  2. Hicheri J, Jaber K, Dhaoui MR, Youssef S, Bouziani A, Doss N. Giant condyloma (Buschke-Löwenstein tumor). A case report. Acta Dermatovenerol Alp Pannonica Adriat. 2006;15(4):181–3. PMID: 17982612.
  3. Gürbulak EK, Akgün İE, Ömeroğlu S, Öz A. Giant perianal condyloma acuminatum: Reconstruction with bilateral gluteal fasciocutaneous V-Y advancement flap. Ulus Cerrahi Derg. 2015;31(3):170–3. doi: 10.5152/UCD.2015.2838. eCollection 2015.
  4. Martin JM, Molina I, Monteagudo C, Marti N, Lopez V, Jorda E. Buschke-Lowenstein tumor. J. Dermatol. Case Rep. 2008;2:60–2. doi: 10.3315/jdcr.2008.1019.
  5. Kolbashova YuN, Afanas’ev DV, Filosofov SYu, Burtsev VV. Giant condyloma Buschke-Levenshtein (clinical observation). Tazovaya khirurgiya i onkologiya. 2019;9(3):54–8. doi: 10.17650/2686-9594-2019-9-3-54-58. (In Russ).
  6. Buschke A, Löwenstein L. Uber carcinomahnliche Condylomata acuminata des Penis. Berliner klinische Wochenschrift. 1925;4:1726–8.
  7. Fanget F, Pasquer A, Djeudji F, et al. Should the surgical management of Buschke–Löwenstein tumors be aggressive? About 10 cases. Dig Surg. 2017;34:247–52. doi: 10.1159/000452496.
  8. Trombetta LJ, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001;44(12):1878–1886.
  9. Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma acuminatum (Buschke-Löwenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum. 1994;37(9):950–957.
  10. Creasman C, Haas PA, Fox TA Jr, Balazs M, Creasman C, Haas PA, Fox TA Jr, Balazs M. Malignant transformation of anorectal giant condyloma acuminatum (Buschke-Löwenstein tumor). Dis Colon Rectum. 1989;32:481–487.
  11. Frega A, Stentella S, Tinari A, Vecchione A, Marchionni M. Giant condyloma acuminatum or Buschke-Lowenstein tumor: review of the literature and report of three cases Treated by CO2 laser surgery. A long term followup. Anticancer Res. 2002;22:1201–1204.
  12. Men’shikov KV, Pushkarev VA, Urazin RR, Pushkarev AV. Surgical treatment of giant condyloma Buschke-Levenshtein. Meditsinskii vestnik Bashkortostana. 2018;13,6(78),8:66–69. (In Russ).
  13. Indinnimeo, et al. Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases. World Journal of Surgical Oncology. 2013;11:231. doi: 10.1186/1477-7819-11-231.
  14. Safi F, Bekdache O, Al-Salam S, Alashari M, Mazen T, El-Salhat H. Management of peri-anal giant condyloma acuminatum – a case report and literature review. Asian J Surg. 2013;36(1):43–52. doi: 10.1016/j.asjsur.2012.06.013.
  15. Trombetta LG, Place RJ. Giant condyloma accuminatum of the anorectum: report of a case and review if the literature. Dis Colon Rectum. 2001;44:1878–1886.
  16. Dawson DF, Duckworth JK, Bernardt H. Giant condyloma and verrucous carcinoma of the genital area. Arch Pathol. 1976;79:225–231.
  17. Orkin BA. Perineal reconstruction with local flaps: technique and results. Tech Coloproctol. 2013;17:663–670.

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Swelling of the perineum with the transition to the perianal region. Postoperative scars are visible as a result of previous attempts to remove the tumor

Download (497KB)
3. Fig. 2. Type of the operating wound. The wound area is more than 200 cm2

Download (780KB)
4. Fig. 3. A – type of postoperative wound on the 4th day after surgery, healing by primary intention, skin flaps are viable, no necrosis. B – view two months after surgery, moderate swelling of the labia majora with a tendency to resolve. No relapse was found

Download (502KB)
5. Fig. 4. Papillomatosis and distinct acanthosis with pronounced vacuolization of cells. Epidermal processes are thickened and elongated. Staining with hematoxylin and eosin (× 40)

Download (545KB)

Copyright (c) 2021 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС 77 - 86496 от 11.12.2023 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ЭЛ № ФС 77 - 80673 от 23.03.2021 г
.



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies