Vol 26, No 1 (2021)

BACKGROUND: Male breast cancer is considered a rare condition – less than 1% of all breast cancer cases. 1607 cases of breast cancer were diagnosed by 2019 in Krasnoyarsk region and only 5 cases (0,31%) of the disease were in male patients.

AIM: This study aims to conduct a retrospective analysis of cases of breast cancer treatment in males in the Krasnoyarsk Territory for the period 1998–2019, as well as to assess overall and progression-free survival rates in this category of patients.

MATERIALS AND METHODS: A total of 28 males with diagnosed breast cancer received treatment at the Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky in the period from 1998 to 2019.

RESULTS: Since 2013, an increase in breast cancer in males is noted in the Krasnoyarsk Territory. Average age of the patients at the time of diagnosis was 60.3±10.3 (range – 35 to 83 years). Allocating patients to the clinical stages: 8 patients (28.6%) were diagnosed with stage I of the tumor process, stage II was revealed in 12 (42.9%) patients, stage III was diagnosed in 7 (24.9%) patients and in 1 case (3.6%) cancer was found in situ. Metastatic lesions of the lymph nodes were revealed in 11 patients (39.3%): N1 – 9 patients (81.8%), N2 – 1 patient (9.1%), N3 – 1 patient (9.1%). Luminal A subtype was diagnosed in 3 patients (13.6%), luminal B (HER2-negative) – in 16 patients (72.8%), luminal B (HER2-positive) – in 2 patients (9.1%). 75% of patients received adjuvant therapy. As a result of the treatment, stabilization of the process was registered in 64.3% of cases. 4 patients (14.3%) suffered from recurrence of the disease; 2 patients (7.1%) were diagnosed with multiple primary cancer. For the entire observation period, fatal cases composed 4 (14.3%). Analysis of the overall survival rates for the male patients with breast cancer demonstrated a positive effect of endocrine therapy.

CONCLUSION: The results obtained indicate an increase in the incidence of breast cancer in men in the Krasnoyarsk Territory. Men have the tumor which is hormone-positive and administration of hormone therapy in the adjuvant mode increases overall survival rates.

В-cell lymphoma is manifested by a variety of forms, which makes it difficult to establish an accurate lifetime diagnosis and has an unfavorable prognosis. Therefore, every case of primary B-cell lymphoma of the breast, demands attention close attention of doctors of different specialties. The feature of the presented investigation is B-cell lymphoma, that primarily affects the right breast. This type of breast cancer develops as chronic mastitis, confirming the variety of forms of its manifestation, what cause difficulties in making accurate primary diagnosis.