Coordination Compounds of 3d Metals with 2,4-Dimethylpyrazolo[1,5-а]benzimidazole: Magnetic and Biological Properties

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Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

New coordination compounds of copper(I), copper(II), cobalt(II), and nickel(II) with 2,4-dimethylpyrazolo[1,5-а]benzimidazole (L) were synthesized and studied. The complexes [CuLCl] (I), [CuLBr] (II), [CuL2Cl2] (III), [CuL2(NO3)2] · H2O (IV), [CoL2Cl2] · 0,5H2O (V), [CoL2(NO3)2] · · 0,5H2O (VI), and [NiL2(NO3)2] · 0,5H2O (VII) were studied by IR spectroscopy and powder and single crystal X-ray diffraction (CCDC nos. 2321779 ([CuL2Cl2]), 2321780 ([CoL2(NO3)2])). The results indicate that the coordination polyhedron in 2,4-dimethylpyrazolo[1,5-a]benzimidazole complexes is formed by the nitrogen atoms of the monodentate ligand and the coordinated anion. The cytotoxic and cytostatic properties of L and complexes I–III were studied in relation to the HepG2 hepatocellular carcinoma cells.

Толық мәтін

Рұқсат жабық

Авторлар туралы

O. Shakirova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences; Komsomolsk-on-Amur State University

Хат алмасуға жауапты Автор.
Email: Shakirova_Olga@mail.ru
Ресей, Novosibirsk; Komsomolsk-on-Amur

T. Kuz’menko

Institute of Physical and Organic Chemistry, Southern Federal University

Email: Shakirova_Olga@mail.ru
Ресей, Rostov-on-Don

N. Kurat’eva

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Ресей, Novosibirsk

L. Klyushova

Institute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine

Email: Shakirova_Olga@mail.ru
Ресей, Novosibirsk

A. Lavrov

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Ресей, Novosibirsk

L. Lavrenova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Ресей, Novosibirsk

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1. JATS XML
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2. Scheme 1.

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3. Scheme 2.

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4. Fig. 1. Molecular structure of the [CuL₂Cl₂] complex.

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5. Fig. 2. Crystal structure of the complex [CuL₂Cl₂

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6. Fig. 3. Hexagonal packing motif of the [CuL₂Cl₂] molecular complexes shown in the ab plane (H atoms omitted for clarity).

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7. Fig. 4. Molecular structure of the [CoL₂(NO₃)₂] complex.

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8. Fig. 5. Crystal structure of the [CoL₂(NO₃)₂] complex

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9. Fig. 6. Hexagonal packing motif of the [CoL₂(NO₃)₂] molecular complexes shown in the ab plane (H atoms omitted for clarity).

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10. Fig. 7. Diffraction patterns of complexes of the composition [CuLHal].

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11. Fig. 8. Diffraction patterns of complexes of composition [ML₂A₂].

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12. Fig. 9. Temperature dependences of the magnetic susceptibility of sample III, measured in magnetic fields H = 1, 10 kOe (a); temperature dependences of the inverse susceptibility 1/χp and the effective magnetic moment µeff, calculated in the approximation of non-interacting ions (θ = 0) (b).

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13. Fig. 10. Field dependences of magnetization M and normalized susceptibility χ(H)/χ(0) of sample III. Dashed lines show the approximation of the data by the theoretical dependence for a system of paramagnetic centers (S = 1/2, g = 2.1) with isotropic AFM interaction zJ/kB = 0.30 K. For comparison, the dotted line shows the theoretical magnetization of a system of the same paramagnetic centers with zJ/kB = 0.8 K (θ ≈ –0.4 K).

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14. Fig. 11. Effect of the studied compounds on the viability of HepG2 cells: 1 – number of cells, 2 – dead cells, 3 – living cells, 4 – apoptotic cells.

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