Vol 20, No 2 (2015)


The first experience of radial artery approach for uterine fibroid embolization

Khayrutdinov E.R., Ignatiev Y.T., Vorontsov I.M., Kravchenko E.N., Tsygankova O.Y., Popov S.P., Leonov O.V.


The authors have used for the first time transradial approach for uterine fibroid embolization. We represent a comparable analysis of transradial and transfemoral approach for uterine fibroid embolization. The major advantages of transradial approach are described.
Russian Journal of Oncology. 2015;20(2):4-7
pages 4-7 views

Clinical efficiency of intra-cavity biotherapy patients with malignant effusions

Titov K.S., Demidov L.V., Shubina I.Z., Gritsay A.N., Egorova A.V., Kiselevsky M.V.


The study evaluatedfeasibility, safety and effectiveness of cell biotherapy based on allogenic LAK-cells in combination with recombinant interleukin-2 (IL-2) used for sistem antitumor immunotherapy. The clinical study involved cancer patients with metastatic effusions resistant to systemic chemotherapy. The results showed that intra-cavity immunotherapy was highly effective and well tolerated in treatment of patients with malignant effusions.
Russian Journal of Oncology. 2015;20(2):8-12
pages 8-12 views

Some indices of neoplastic angiogenesis in tissues of rectal tumors with various morphological structures

Kit O.I., Frantsiyants E.M., Nikipelova E.A., Komarova E.F.


The development and growth of the neoplasm is carried out directly by the ability to produce angiogenic factors that stimulate neovascularization. In the tumors of the rectum of various origins (primary adenocarcinoma of stage III (n = 73) and polyps (n = 35): tubular adenoma, villous adenoma, tubular-villous adenoma) the performance of tissue fibrinolytic system and the level of growth factors was studied. A common feature in the tissue of colorectal cancer and polyps is the high content of VEGF-A, VEGF-R and TGF-β1, as well as the increased formation of plasmin, which indicates an increase in angiogenesis and cell proliferation processes violation tissue. Expression of growth factors and functioning of the fibrinolytic system in the case of malignant’s transformation is in better interaction and mutual influence and has a greater number of correlations. In tissue polyps indicators of studiedfactors generally occupy an intermediate position between the cancer and the intact tissue, which shows the possible ways of their cancer’s transformation.
Russian Journal of Oncology. 2015;20(2):12-18
pages 12-18 views

Characteristics of lymphocyte subpopulations intratumoral ovarian cancer

Nikoghosian S.O., Tupitsyn N.N., Mozhenkova A.V., Kokosadze N.V., Levitskaya N.V., Zueva E.V., Kuznetsov V.V.


The article presents some mechanisms of antitumor immunity, lymphocyte subpopulations present in tissues of serous ovarian cancer were studied (intratumoral lymphocytes). The composition of intratumoral lymphocytes in tumor stroma, depending on its degree of differentiation was studied. A significant relationship between the degree of infiltration of mature T cells and the degree of differentiation of serous ovarian cancer was revealed.
Russian Journal of Oncology. 2015;20(2):18-21
pages 18-21 views

Modern possibilities of cytological methods in the differential diagnosis of metastatic lesions in mediastinal lymph nodes

Marinov D.T., Mekheda L.V., Polotskiy B.E., Laktionov K.K.


The comparative analysis data of immunocytochemistry and mmunohistochemistry studies mediastinal lymph nodes. Immunocytochemical method is not inferior in their capabilities by immunohistochemistry in the differential diagnosis of metastatic lymph nodes of the mediastinum.
Russian Journal of Oncology. 2015;20(2):21-25
pages 21-25 views

Multiple primary squamous cell carcinoma of the oropharynx and hypopharynx. Case report

Kropotov M.A., Agabekyan G.O., Stelmakh D.K., Saprina O.A., Lysov A.A., Badalyan A.G., Dronova E.L.


The article presents a clinical case of radical surgery using microsurgical techniques for cancer of the oropharynx after complex therapy spent the first tumor - hypopharynx cancer.
Russian Journal of Oncology. 2015;20(2):26-28
pages 26-28 views

The use of post-genomic technologies for the diagnosis of cancer on the example of prostate cancer

Peshkov M.N., Sharova E.I., Klabukov I.D.


The last ten years have significantly changed the diagnostic and therapeutic technologies in research and practice. Human genome from a large international project turns into a basis of personalized medicine. The paper presents the positive experience of the new technology experimental thinking that led to the creation of complex scientific and technological platform that allows you to significantly improve the diagnostic characteristics (sensitivity, specificity) of the traditional PSA test. This paper presents the experimental results, which can improve the specificity and sensitivity of existing diagnostic methods.
Russian Journal of Oncology. 2015;20(2):29-32
pages 29-32 views

Growth factors vascular of endothelial and receptors in the dynamic of transplantable melanoma B16/F10 development

Frantsiyants E.M., Bandovkina V.A., Kaplieva I.V., Trepitaki L.K., Pogorelova Y.A., Cheryarina N.D.


The growth of any cancer is associated with neoangiogenesis and neolimfogenezom that gives neoplasm opportunity of autonomous development. The basic processes of these agents is the family of vascular endothelial growth factor (VEGF), represented by VEGF-A, VEGF-C, VEGF-D, its biological effects performing the interaction with tyrosine kinase receptors R1, R2 and R3. In tumor and perifocal zone intact skin of laboratory animals - mice were inoculated subcutaneously with B16 melanoma / F10 (n = 40) to study the dependence of the level of VEGF-A, VEGF-C, as well as their receptors - R1, R2 from the development of cancer. It was found that during the growth of melanoma B16 / F10 in mice lines C57BL / 6j actively implemented mechanisms of various vessels creation - angiogenesis, and vasculogenic mimicry neolimfogenesis. Thus growth factors and their receptors are synthesized not only the tumor, but also to surrounding tissues, and even remote areas of the skin from the tumor. Until the second week of melanoma tumor is a leading component for expression of growth factors and their receptors, however, for the third week - the lead passes to the perifocal area, which continues to increase as VEGF, and their receptors. Interestingly time that remote from the tumor of the skin is much more active synthesis of VEGF-C and its receptor.
Russian Journal of Oncology. 2015;20(2):32-37
pages 32-37 views

Characteristics of distribution frequency of GSTM1 and GSTT1 polymorphic genes among residents of Mongolia

Uyanga G., Zandraa J., Gandbold S., Unursaikhan S., Altanchimeg O., Suvd D.


Intensive urbanization and socioeconomic development since the beginning of the 1990s significantly changed lifestyles of Mongolians as well as is resulted in rapid epidemiological transition in morbidity and mortality patterns. In regard to this we studied polymorphism of GSTM1 and GSTT1 genes null genotypes in Mongolian population in order to observe the influence of these negative to the heath socio-economic impacts on frequencies of GSTM1 and GSTT1 genes null genotypes in people born after 1990.
Russian Journal of Oncology. 2015;20(2):38-42
pages 38-42 views

Malignancies in children in Russia: trends and highlights

Men' T.K., Rykov M.Y., Polyakov V.G.


Objective - to determine current rates of childhood cancer incidence and mortality at a national level for Russia and to evaluate recent trends. Material and methods. Using the Annual reports of Ministry of health and Federal State Statistics Service we calculated childhood cancer incidence and mortality rates for the 5-year period 2008-2012 and trends between 1989 and 2012 by sex, age and site. Rates were directly age-standardised to the 2000 World Standard Population, and linear regression was used to determine the magnitude and significance of trends. Results. The age-adjusted incidence rate in children aged 0-17 years was 125 per 1,000, 000 individuals per year for 2008-2012. The highest age-specific incidence (159 per 1,000,000 children/year) was observed in early childhood (0-4 years). Between 1989 and 2012, a significant increase in the cancer incidence was observed in children aged 0-14 years: average annual percent change was 1,6% [95%CI 1,5%; 1,7%]. The greatest increase for this period was observedfor soft tissue sarcomas (3,7% [2,6; 4,9]), hepatic tumors (3,6% [2,6; 4,6]), thyroid carcinomas (3,7% [3,2; 4,2]), CNS neoplasms (2,9% [2,6; 3,1]), renal tumors (2,1% [1,7; 2,5]) and leukaemias (1,9% [1,7; 2,1]). The decrease of incidence was observed for Hodgkin (- 1,6% [-2,1; -1,2]) and non-Hodgkin (- 1.4% [-1,8; -1,0]) lymphomas. Childhood cancer mortality for 2008-2012 was 40 cases per 1000,000 children/year. The highest age-specific mortality rate (52,3 per 1,000,000) was observed in infants. The significant decrease of mortality were found from 1989 (70 per million) to 2012 (37per million). The greatest average annual decrease for this period was observedfor leukaemias (-3,8% [-4,0; -3,5]) and lymphomas (-6,8% [-7,3; -6,4]). The significant decrease of mortality in 19992012 was foundfor malignant bone tumors( -5,9% [-7,4; -4,3]), renal tumors (-2,9% [-4,7; -1,1]) and CNS neoplasms (-1,1% [-1,9; -0,3]) with the only exeption for soft tissue sarcomas (average annual increase was 3,2% [1,8; 4,7]). Conclusion. Significant temporal trends of childhood cancer incidence and mortality in Russia were found during the study period. Although rates of cancer mortality are generally decreasing in Russia there are still very high levels for common childhood cancer types.
Russian Journal of Oncology. 2015;20(2):43-47
pages 43-47 views

Sunitinib - standard second-line therapy of metastatic gastro-intestinal stromal tumors (review of literature and case reports)

Meshcheryakov A.A., Filonenko D.A., Petukhova S.V.


Treatment of gastrointestinal stromal tumors actively developed. Standard second-line treatment of disseminated gastrointestinal stromal tumors is sunitinib (Sutent). Its effectiveness is proven in a randomized, double-blind, multicenter, international phase III trial NCT 00075218. This review summarizes recent data on the epidemiology and diagnosis of the disease, a common approach to the treatment of early and advanced disease, the results of the registration study of sunitinib phase III clinical recommendations to reduce the frequency and severity of adverse events. Particular attention is paid to the factors that are key to achieving the maximum clinical efficacy of sunitinib, namely, prevention and treatment of adverse events, optimizing the dosage regimen and duration of treatment. The article illustrates own clinical observations that demonstrate the efficacy of sunitinib as second-line therapy of disseminated gastrointestinal stromal tumors.
Russian Journal of Oncology. 2015;20(2):48-53
pages 48-53 views

Galina Andreevna Nerodo (on the occasion of her 75 th birthday anniversary)

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Russian Journal of Oncology. 2015;20(2):54-55
pages 54-55 views

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