Vol 19, No 2 (2014)


Extensive liver resection with preoperative chemotherapy for colorectal metastases with high risk of complications

Patyutko Y.I., Mamontov K.G., Kotelnikov A.G., Ponomarenko A.A., Lazarev A.F.


Objective: to study influence of preoperative chemotherapy on postoperative complications rate. Material and methods: an analysis of 455 cases of extensive liver resection. 229 (56%) patients didn’t receive neoadjuvant chemotherapy, 176 (44%) - received preoperative chemotherapy. 216 (53%) patients had bilobar lesions, 156 (39%) - had multiple metastases, 168 (42%) - had synchronous metastases, 237 (58%) - had metachronous metastases. 60 (15%) patients in addition to liver lesions, had been resected for extrahepatic metastases. Results: bevacizumab inckusion to preoperative regional chemotherapy did not lead to increase of postoperative complication rate. Conclusion: Postoperative complication rate didn’t significantly differ in all groups of treatment, regardless of liver resection volume. Extension of liver resection from standard hepatectomy to extensive, leads to statistically significant increase of acute hepatic failure. Acute hepatic failure takes the first place among complications (21%).
Russian Journal of Oncology. 2014;19(2):4-11
pages 4-11 views

Combined operations in conjunction with intracavitary chemotherapy for treatment of patients with peritoneal mesothelioma. Immediate results. Experience of the Thoracic Department of the N.N. Blokhin Russian Cancer Research Center of RAMS

Abdullaev A.G., Polotskiy B.E., Davydov M.I.


The paper presents a detailed analysis of the immediate results of the treatment of patients with peritoneal mesothelioma who underwent cytoreductive surgery combined with intracavitary hyperthermia chemoperfusion in the thoracic department of the N.N. Blokhin Russian Cancer Research Center in the period from 2008 to 2013.
Russian Journal of Oncology. 2014;19(2):12-15
pages 12-15 views

Association between the morphological characteristics of growth and the clinical course of oral cancer

Samedov V.H., Naleskina L.A., Zakharychev V.D.


Clinical-morphological study based on the clinical data of 122 patients with malignant neoplasms of tongue and oral mucosa was conducted aimed at establishing an association between the morphological characteristics of malignant tumors and symptomatic progression of the tumor process conducted after treatment. It was demonstrated that all tumors with epithelial genesis, 107 represented a keratinizing squamous carcinoma, and the degree of differentiation prevailed moderately differentiated tumors (113 cases). Retrospective evaluation of the malignancy degree of tongue and oral mucosa tumors, according to recommendations in literature, conducted before treatment, showed a prevalence in all groups studied tumors grade III compared to II and a small number of tumors with I degree of malignancy. When comparing the degree of malignancy of squamous cell carcinoma in each studied group of patients with clinical diagnosis of tumor progression: the time of relapse and regional metastases after treatment established an association between these indicators. The most aggressive growth characterized by squamous cell carcinoma grade III, despite the pronounced signs of keratinization in most tumors. The most effective was the complex treatment of patients with combined effects of CRT + CD and microwave hyperthermia. Reported patterns give rise to speak about the possibility of using morphological grade squamous cell carcinoma of tongue and oral mucosa, as a predictive clinical and morphological parameters of the flow of the tumor process.
Russian Journal of Oncology. 2014;19(2):16-21
pages 16-21 views

Research of topoisomerase A.F. lia activity in conjunction with clinical and morphological parameters and proliferation (to identify argyrophilic proteins of nucleolar organizer regions and antigen Ki-67) in squamous cell carcinoma of the lung

Kobyakov D.S., Bychkova E.Y., Avdalyan A.M., Bobrov I.P., Lazarev S.A., Kruglova N.M., Lushnikova E.X., Lazarev A.F., Nepomnyashchikh L.M.


Topoisomerase IIα (TopoIIα), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and antigen Ki-67 in squamous cell carcinoma of the lung were investigated. Defined Tumors with low and high TopoIIα, Ag-NOR and Ki-67 were defined. TopoIIα had a relationship with clinical and morphological parameters (value T, greatest dimension, stage of disease and tumor differentiation) and proliferation markers (Ag-NOR, Ki-67). Survival of patients with squamous cell carcinoma of the lung with low content of TopoIIα is better as compared with high content of TopoIIα. Survival of patients depends on the mutual content of TopoIIα and clinical and morphological parameters (value N, stage of disease), proliferation markers (Ag-NOR). TopoIIα and Ag-NOR are independent prognostic factors. Mutual research of TopoIIα with clinical and morphological parameters and Ag-NOR has prognostic value in squamous cell carcinoma of the lung.
Russian Journal of Oncology. 2014;19(2):22-26
pages 22-26 views

Organization of medico-social work in medical institutions, which provide specialized and high-tech care for children hematologic malignancies

Zhukovskaya E.V., Novichkova G.A.


The steadily increasing importance of medical and social measures, focused on patients with oncohaematology pathology. It is extremely important to identify the most significant problems in the practice of doctor working on a profile “child oncohaematology” during the expert work to develop measures to optimize this type of activity in the modern world. There results of the survey of experts in 40 largest Russian clinics are submitted. These features of oncology specialists at the whole stages of treatment could impact the possibility of access to social benefits guaranteed by the state to families with disabled children. Necessary to improve the rehabilitation of patients to end their terms of disability was accompanied by a successful social integration in society.
Russian Journal of Oncology. 2014;19(2):27-31
pages 27-31 views

Gestational trophoblastic disease: classification and prognostic factors (part II)

Bistritskaya D.A., Tikhonovskaya M.N., Mescheryakova L.A., Kuznetsov V.V., Davidova I.Y.


Study of factors affecting the prognosis of malignant trophoblastic tumors, allow adequate treatment plan. Histological form trophoblastic tumor has important prognostic value. Chorionic carcionoma and epithelioid tumors are characterized by a worse prognosis, it is difficult to predict the prognosis for placental trophoblastic tumor and the most favorable prognosis is expected in the invasive and metastatic hydatidiform mole. Important prognostic factors are the age of the patient, the outcome of the previous pregnancy disease, length of history, the initial level of beta-human chorionic gonadotropin tumor size, location, size and number of metastases. Inadequate chemotherapy prior to standard treatment, contributes to the emergence of drug resistance of tumors and significantly worsens the prognosis. Modern FIGO classification 2000, includes clinical staging scale and prognostic factors based on which you plan to standard chemotherapy trophoblastic tumors.
Russian Journal of Oncology. 2014;19(2):32-36
pages 32-36 views

Intraoperative radiation for breast cancer

Korytova L.I., Manikhas G.M., Minaeva E.A.


Breast cancer is in the first place in the global structure of the women cancer incidence. Radiation therapy is one of the methods in the treatment of breast cancer. This article focuses on one type of radiation therapy - intraoperative radiation therapy. The data on the experience of using this method of treatment is published.
Russian Journal of Oncology. 2014;19(2):36-39
pages 36-39 views

Hereditary breast cancer

Lazarev A.F., Zadontseva N.S., Gofman A.A.


Ten million new cases of a cancer and more than 6,2 million death from diseases of this group are registered annually in the world. From 5 to 40% of malignant new growths of all anatomic localizations have a hereditary etiology, and this percent increases in connection with growth of the general incidence. The Cancer of a Mammary Gland (CMG) is the most widespread oncological pathology at women. Both in the world, and in Russia, despite significant progress in development of approaches to diagnostics and to CMG treatment within the last decades incidence, prevalence and mortality from CMG remain steadily high and tend to growth.
Russian Journal of Oncology. 2014;19(2):40-46
pages 40-46 views

Different types of sentinel lymph node biopsy in breast cancer patients

Afanasyeva K.V., Petrovskiy A.V., Nechushkin M.I., Shiryaev S.V., Zaytseva A.A.


Novel data on biological features of tumors and diagnosis development have become an stimulus to reduce surgical extension for breast cancer. Axillary lymph node dissection is associated with different complications. That’s why a demand to verify regional lymph node status using biopsy has appeared. Sentinel lymph node biopsy (SLNB) is performed in a few steps. First, a marker solution is introduced intradermally or into breast parenchyma periareolarly or at the tumor site. Afterwards it goes with lymph flow to the lymph node and accumulates in it, this first node is called sentinel (SLN). Its localization is variable but most typically it could be found at the lateral margin of major pectoral muscle at the frontal axillar line. There are currently 5 main methods of SLNB that are described in this article. These techniques differ in a substance used and equipment needed to detect a SLN. All the methods are currently implemented routinely. Many investigations has been performed worldwide that shows advantages and disadvantages of each method which are described in the given article.
Russian Journal of Oncology. 2014;19(2):46-51
pages 46-51 views

Radiologic methods in evaluation of prevalence and structure of IVC tumor thrombus in patients with renal cell carcinoma

Vikhrova N.B.


Renal cell carcinoma (RCC) is the most common primary tumor of the kidney; it accounts for approximately 3% of newly diagnosed cancers. The incidence of venous extension to the inferior vena cava (IVC) and renal vein in RCC is markedly increased recently mostly due to the advances in diagnostic modalities. Knowledge of the tumoral stage and determination of tumor thrombus extension at the time of diagnosis is essential for prognosis and surgical planning. Nowadays abdominal ultrasound (US), computed tomography (CT) and magnetic resonance (MR) scanning techniques are used for the detection and staging of RCC. In this study, the accuracy of recent diagnostic tools in determination of IVC thrombus is outlined. Also the role of positron emission tomography (PET) scanning is briefly addressed.
Russian Journal of Oncology. 2014;19(2):51-56
pages 51-56 views

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