Vol 25, No 5 (2020)

In 2019, melanoma affects 66.9 per 100,000 populations in the Russian Federation, which was higher than 44.5 in 2009. Vulvar melanoma is one of the rare localizations of malignant tumors. Its disease course and prevalence differ from those of skin melanoma. Given the rarity of this localization, no large studies have been published in the Russian Federation.

Objective. This study aimed to study the clinical course and prevalence of vulvar melanoma in the Republic of Bashkortostan.

Materials and methods. A retrospective analysis of the clinical course of malignant tumors of the external genital organs was carried out in 324 patients within a 5-year period. Vulvar melanoma was diagnosed in 23 cases, which accounted for 6.5% of the total number of patients with malignant neoplasms of the female external genital organs. The clinical course and medical data in 23 patients diagnosed with vulvar melanoma were evaluated. The disease stage, characteristics of the clinical course, and presence of BRAF and c-KIT mutations were assessed. In the Republic of Bashkortostan, the incidence of vulvar melanoma was estimated based on the data of the Republican Clinical Oncological Dispensary.

Results. Within 5 years, 23 patients were diagnosed with vulvar melanoma, which is a very small proportion relative the total number of patients with cancer. Difficulties in determining the scope of adequate surgical treatment and presence of prognostic factors define the prognosis of the disease. Most of the patients at the first stage of the disease received surgical treatment. The scope of surgical treatment was based on the localization of the primary tumor and the presence of metastases in regional lymph nodes.

Conclusion. Vulvar melanoma is a rare and aggressive malignant tumor. In the Republic of Bashkortostan, as well as in the Russian Federation, no register has been established for this localization. In view of the anatomical features of this zone, the tumor develops more aggressively and characterized by early lymphogenous metastasis. In patients with fairly young age, an aggressive disease course requires special attention.

Giant condyloma Buschke-Levenshtein is a large, exophytic, slow-growing, benign, warty lesion of the anogenital region. The cause of this pathology is infection with the human papillomavirus, mainly of the 6th or 11th type. The pathogenesis of giant genital warts is not well understood, and it is often considered an intermediate link between acute warts and squamous cell carcinoma. The frequency of occurrence in the general population is about 0.1%, which indicates the rarity of this pathology. The giant condyloma Buschke-Löwenstein was first described by the authors Buschke and Löwenstein in 1925. Currently, the literature contains descriptions of mostly single observations of patients with this pathology. The main method of treatment for giant condyloma Buschke-Levenshtein is surgical, the task of which is a wide excision of the tumor within healthy tissues. We present a clinical observation of a patient with a giant condyloma Buschke-Levenshtein. a 36-year-old patient underwent surgical treatment - removal of a large perineal tumor. At the time of surgery, the size of the tumor was about 25 × 15 cm. The patient underwent surgical treatment without complications, healing by primary intention. Within six months after the operation, no recurrence of the disease was detected. Thus, surgical treatment of such tumors is the only method that can count on the patient being cured.