Vol 19, No 3 (2014)

Articles

PREOPERATIVE CORRECTION OF WATER-ELECTROLYTE DISTURBANCES IN PATIENTS WITH ACUTE INTESTINAL OBSTRUCTION CAUSED BY COLON CANCER

Neymark M.I., Zhukov A.S.

Abstract

Comparative evaluation of preoperative infusion therapy in 50 patients with acute intestinal obstruction of tumour genesis has been performed and parameters of central hemodynamic and water sectors of organism were studied. The patients had a statistically significant reduction of extracellular sector, hypokalaemia, hypornatremia. Central hemodynamic parameters were characterized by a significant reduction in stroke volume and heart rate increase. Mean arterial pressure and peripheral vascular resistance, resistivity reduced in comparison with control group. The study showed that infusion therapy, which includes a balanced colloid solution (HES 130/ 04) and a balanced 700 ml and 1700 ml (average) crystalloid solution and is conducted for 3 hours reduces the severity of water-electrolyte and hemodynamic changes, reduces the need in vasopressor support, and to a certain extent improves outcomes of surgical treatment.
Russian Journal of Oncology. 2014;19(3):4-8
pages 4-8 views

MODIFICATION OF PANCREATICOBILIARY TRACT RECONSTRUCTION AFTER PANCREADUODENECTOMY IN CHILDREN WITH PANCREATIC TUMOURS

Shchepotin I.B., Lukashenko A.V., Klimnyuk G.I., Kolesnik E.A., Priymak V.V.

Abstract

Pancreatic tumours are rare at a young age. For malignancies affecting the head of the pancreas the optimal surgical treatment is pancreaticoduodenectomy (PD). Due to the rare experience of pancreaticoduodenectomy in children, most of the information reported in the literature has been provided in the form of isolated case reports. Material and methods. We performed new type of reconstruction after PD in children. Our reconstructive method aims at a complete separation of passage of gastric contents, bile and pancreatic juice. Thus we prevent any types of possible refluxes and related complications (pancreatic leakage, cholangitis, gastric ulceration). Results. The method has been effectively performed is two patients: 5 year girl, 1 year and 10 month boy with a solid pseudopapillary tumour and malignant teratoma in the head of the pancreas. In postoperative period we did not registered any sights of pancreatic fistula. Patients were discharge on days 9 and 11 respectively. Conclusion. In view of the absence of the data about later physiological outcomes after PD in children we propose our method of pancreaticobiliary reconstruction as safe and physiologically appropriable. PD for children should be performed in institutions where experienced hepato-pancreato-biliary surgeons using modern surgical technologies perform a high volume of cases.
Russian Journal of Oncology. 2014;19(3):8-14
pages 8-14 views

THE INITIAL RESULTS OF REMOTE MAMMOGRAPHY BREAST CANCER SCREENING

Kochergina N.V., Ivankina O.V., Zamogilnaya Y.A., Bludov A.B., Kiselev I.L., Kudentsova G.V., Shultseva E.V., Karpova M.S.

Abstract

The use of mammography breast cancer screening in the world allows to reduce mortality from this widespread disease by 15-30% in the general women population. Currently in the U.S. and in many European countries different standards of mammography screening, which principles are the same and widely applied. The mammography examination standardization and its interpretation is generally accepted for differentiation of the entire flow of healthy women included in the screening process into groups that require different recommendations for monitoring after the first round of screening. To reduce errors in the reports of mammograms the double reading by two radiologists is widely used. Since the program of the medical examination of the Russian Federation population has been enacted, according to which every woman after 39 years has to be examined with radiographic mammography every three years, the question of this process standardization has arisen in order to reduce mortality from breast cancer in the Russian regions.
Russian Journal of Oncology. 2014;19(3):15-18
pages 15-18 views

ALGORITHM OF TREATMENT APPROACHES IN MEDIASTINAL NON-CHROMAFFIN PARAGANGLIOMAS

Zakharychev V.D., Krotevitch M.S.

Abstract

The results of different methods of radical and palliative treatment in 26 patients with intrathoracic localization of nehromafinnoy paraganglioma, 24 tumors were located in the front, one - in the posterior mediastinum, and one - in the pericardial cavity. Malignant paragangioma was confirmed morphologically in 25 observed patients. Surgical intervention is undertaken in 17 patients, of whom 12 had surgery as an integral stage of complex or combined treatment, in 3 - self-treatment and 2 - exeprimental thoracotomy. Combined treatment including preoperative radiotherapy (RT) followed by surgery was undertaken by 6 patients. Comprehensive treatment including neoadjuvant chemotherapy (CT) was received by 6 patients and in combination with radiotherapy by 3 patients. In 5 of these patients the technique of regional intra-arterial administration of anticancer chemotherapy was used. Patients with the presence of distant metastases performed palliative treatment: 4 - LT, 5 - HT. Conclusion: for the radical treatment of malignant paraganglioma method of choice should be a comprehensive treatment with neoadjuvant intra-arterial regional chemotherapy.
Russian Journal of Oncology. 2014;19(3):19-24
pages 19-24 views

COMPARISON OF EFFICACY AND TOLERANCE OF THE INTRAPERITONEAL CELL-BASED AND IL-2 IMMUNOTHERAPY OF PATIENTS WITH CHEMOTHERAPY-RESISTANT GASTRIC CANCER AND MALIGNANT ASCITES

Titov K.S., Demidov L.V., Shubina I.Z., Kiselevsky M.V.

Abstract

Most often gastric cancer is accompanied with abdominal carcinomatosis tumor (metastases) ascites (25 %), which is a life-threatening complications of tumor process, often recurring after systemic drug therapy which not always leads to a longer remission, but is also accompanied by severe side effects. Intraperitoneal immunotherapy of metastatic ascites interleukin-2 (IL-2) in combination with allogeneic (donor) lymphokine - activated killer (LAK) and IL-2 monotherapy is highly effective and well tolerated in patients with gastric cancer. Objective effect of the treatment was 50.0 % and 42.8 %, respectively. Proposed form of immunotherapy can be considered as one of the stages combined drug treatment, has good tolerance and improves their quality of life.
Russian Journal of Oncology. 2014;19(3):24-28
pages 24-28 views

SIDE EFFECTS OF TWO REGIMENS OF TRIPLE-COMPONENT CHEMOTHERAPY (CAPECITABINE, OXALIPLATIN AND IRINOTECAN) AS FIRST-LINE TREATMENT OF METASTATIC COLORECTAL CANCER

Semenov N.N., Meshcheryakov A.A.

Abstract

Last ESMO and NCCN recommendations for the treatment of metastatic colorectal cancer include the use of a triple-component chemotherapy. A study of two modes with the inclusion of irinotecan dose of 120 mg/m2 every 2 weeks, oxaliplatin 85 mg/m2 every 2 weeks, the dose of capecitabine 1600 mg/m2/day in 1-7 days with a 1- week break or 1600 mg/m 2 / day in days 1-14 with a 2-week break. Both modes showed satisfactory tolerance without significant gastrointestinal and hematological toxicity. Plan to further study the development of ternary diagrams for the application of the algorithm implementation in a wide oncological practice.
Russian Journal of Oncology. 2014;19(3):29-31
pages 29-31 views

CLINICAL CASES OF SUCCESSFUL TREATMENT OF PATIENTS WITH METASTATIC PLEURAL MESOTHELIOMA

Karpenko T.D., Bychkov M.B.

Abstract

A modern approach to customize treatment based on careful observation of minimal manifestations of the disease, the prescription of Alimta in the first -line treatment with a combination of platinum drugs can control the disease in the extensive stage and maintain a good state of active patients without objective effect for a long time.
Russian Journal of Oncology. 2014;19(3):32-34
pages 32-34 views

PREDICTION OF BREAST CANCER POSSIBILITY IN THE GENERAL HEALTH NETWORK

Barateli V.T., Taschiev R.K.

Abstract

Aim of this study is to formulate an algorithm based on neural network modelling to calculate the index of individual risk of breast cancer (BC). We examined 1440 women. All subjects aged 18 to 85 years. To achieve the objective used clinical, laboratory and instrumental methods (mammography, ultrasonography). Questionnaire method, methods for constructing artificial neural network models and logistic regression models, as well as the program «oncologist» are based on a neural network. 12 women of 360 clinically healthy women surveyed were assigned to high-risk group. The majority were women 41-50 age group - (75 ± 0,1%). Women aged 51-60 totalled 16,7 ± 0,1%, in 31-40 years - 8,3 ± 0,1%. In the «medium risk» assigned 95 women - 26,4 ± 0,1%, in the « low risk « - 253 women 70,3 ± 0,1%. Statistically significant differences (p < 0,001). Belonging to high-risk groups increases the reliability of the pathological process in 2.2 (CI 1,4-3,5 ) times (p < 0,001). In women at high and medium risk of developing breast cancer as a result of a comprehensive survey found suspected breast cancer one woman (by histological examination - fibroadenoma), fibro-cystosis disease (FCD) in 18 women with one woman - fibroadenoma of the breast. In the low-risk group for breast cancer FCD was detected in 4 women, nodules were not identified. Statistically significant (p < 0,001) risk factors were set up for each age group in the Bukovynskoy region, which make up the largest proportion. An automated system (based on a neural network, which allows you to create « high-risk « of breast cancer and precancerous diseases. Sensitivity of predictive models - 79,8%, specificity - 79,0% with 86,3% diagnostic accuracy.
Russian Journal of Oncology. 2014;19(3):35-38
pages 35-38 views

CURRENT CRITERIA OF RADIAL DIAGNOSTICS TO ASSESS THE EFFECTIVENESS OF SPECIFIC CANCER TREATMENT

Gelezhe P.V., Morozov S.P., Mandelblat Y.E., Libson E.I.

Abstract

Evaluation of tumor treatment response plays an important role in oncology. There were no precise methods for pre-operative assessment of tumor size until the wide introduction of CT and MRI. WHO criteria were introduced in 1979 were the first, but they had considerable limitations. It was the reason for creation of the relevant RECIST 1.0 and 1.1. With invention of new chemotherapy protocols approaches to treatment response assessment were changed. Therefore, new criteria of response to therapyf or some specific histological types of malignant tumors were developed. During the last few years, a necessity for developing specific treatment response criteria using PET/CT emerged; PERCIST 1.0 criteria are a useful tool for evaluation of tumor response by PET/CT. Wide usage of PERCIST 1.0 allows improved assessment of therapy response in general.
Russian Journal of Oncology. 2014;19(3):39-46
pages 39-46 views

MOLECULAR GENETIC FEATURES OF PERITONEAL PSEUDOMYXOMA

Shahpazyan N.K., Abdullayev A.G., Polotskiy B.E., Mekheda L.V., Davydov M.I.

Abstract

The article analyzes the modern molecular genetic features pseudomyxoma of the peritoneum in order to find a possible source and causes of disease, identify the factors of tumor growth, as well as identification of ways to improve current treatments.
Russian Journal of Oncology. 2014;19(3):46-51
pages 46-51 views

DIAGNOSIS AND TREATMENT OF PATIENTS WITH METASTATIC SQUAMOUS CELL CARCINOMA OF THE CERVICAL LYMPH NODES WITHOUT A PRIMARY FOCUS BEING DETECTED

Saprina O.A.

Abstract

The paper presents a review of literature on the most unstudied problem in head and neck oncology - the diagnosis and treatment of patients with cervical lymph node metastases without a primary focus being detected.
Russian Journal of Oncology. 2014;19(3):52-56
pages 52-56 views

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